{"id":272040,"date":"2025-10-07T12:20:38","date_gmt":"2025-10-07T06:35:38","guid":{"rendered":"https:\/\/insurancekhabar.com\/scientists-discover-hidden-viruses-in-hiv-treatment-2\/"},"modified":"2025-10-07T12:20:38","modified_gmt":"2025-10-07T06:35:38","slug":"scientists-discover-hidden-viruses-in-hiv-treatment-2","status":"publish","type":"post","link":"https:\/\/english.insurancekhabar.com\/scientists-discover-hidden-viruses-in-hiv-treatment-2\/","title":{"rendered":"Scientists Discover Hidden Viruses in HIV Treatment"},"content":{"rendered":"<p>Kathmandu. New mRNA nanoparticle technology could be used to activate the hidden HIV virus in the body, scientists say is a &#8220;game changer&#8221;. <\/p>\n<p><span style=\"color: #0000ff;\"><strong>Main challenge in HIV treatment<\/strong><\/span><\/p>\n<p>}<\/p>\n<p>While efforts have been made for decades to completely control HIV, one of the main challenges is the &#8220;hidden virus&#8221;. The virus hides inside the body&#8217;s white blood cells (CD4 plus T cells) and remains dormant. Which cannot be detected by medicine or the body&#8217;s immune system. For this reason, a person infected with HIV has to take medication for the rest of his life. Because the virus is not completely destroyed. <\/p>\n<p><span style=\"color: #0000ff;\">{{TAG_OPEN_strong_42}New discovery: mRNA nanoparticle &#8216;LNP X&#8217;<\/strong><\/span><\/p>\n<p>In 2025, researchers at Harvard Medical School have developed an advanced mRNA-lipid nanoparticle system called LNPX. While the technology is similar to that used in the COVID-19 mRNA vaccine, it has been modified specifically to directly reach the CD4-plus cells that hide HIV. <\/p>\n<p>The mRNA in this nanoparticle makes a protein inside the cell that &#8220;activates&#8221; the SOV virus. Due to which the virus which was previously invisible can now be detected. Previous attempts failed because white blood cells couldn&#8217;t take up nanoparticles. But LNP-X has solved this problem by increasing its ability to cross the cell membrane. <\/p>\n<p><span style=\"color: #0000ff;\"><strong>Laboratory results: Night and day different<\/strong><\/span><\/p>\n<p>Tests on white blood cells taken from HIV-infected people showed a significant increase in viral RNA levels after LNP-X treatment. Scientists call it a &#8220;night and day difference&#8221;. Which means that the hidden viruses have been able to be clearly identified. <\/p>\n<p>This technology has now made the &#8216;shock and kill&#8217; strategy practically possible. Where the virus is first &#8216;awakened&#8217; and then destroyed by the drug or the body&#8217;s immune system. <\/p>\n<p><span style=\"color: #0000ff;\"><strong>Future Prospects and Challenges<\/strong><\/span><\/p>\n<p>This technology does not yet ensure a complete cure for HIV. However, this is a very important step towards ending HIV. In the next phase, this technology will be taken to human trials. It will evaluate its safety, efficacy and long-term impact. <\/p>\n<p><span style=\"color: #0000ff;\"><strong>Main Challenges<\/strong><\/span><\/p>\n<ul>\n<li>mRNA expression control, <\/li>\n<li> to ensure that the body does not have an excessive immune response, <\/li>\n<li>Ensuring mass production and safe delivery. <\/li>\n<\/ul>\n<p>If successful, the LNP-X technology could be useful not only in HIV but also in other hidden viral diseases (such as hepatitis or tuberculosis). <\/p>\n<p><span style=\"color: #0000ff;\"><strong>Conclusion: New Mode of Science<\/strong><\/span><\/p>\n<p>}<\/p>\n<p>Scientists consider this discovery to be a turning point in HIV treatment. The ability to see hidden viruses now opens up a new avenue for researchers to get to the real end of HIV. Just as the COVID-19 vaccine gave worldwide acceptance of mRNA technology, LNPX is expected to usher in a new era of HIV treatment.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Kathmandu. New mRNA nanoparticle technology could be used to activate the hidden HIV virus in the body, scientists say is a &#8220;game changer&#8221;. Main challenge in HIV treatment } While efforts have been made for decades to completely control HIV, one of the main challenges is the &#8220;hidden virus&#8221;. The virus hides inside the body&#8217;s [&hellip;]<\/p>\n","protected":false},"author":16,"featured_media":272038,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[45044,45159],"tags":[],"class_list":["post-272040","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-international-news-en","category-news-en"],"acf":[],"_links":{"self":[{"href":"https:\/\/insurancekhabar.com\/ikbrapi\/wp\/v2\/posts\/272040","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/insurancekhabar.com\/ikbrapi\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/insurancekhabar.com\/ikbrapi\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/insurancekhabar.com\/ikbrapi\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/insurancekhabar.com\/ikbrapi\/wp\/v2\/comments?post=272040"}],"version-history":[{"count":0,"href":"https:\/\/insurancekhabar.com\/ikbrapi\/wp\/v2\/posts\/272040\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/insurancekhabar.com\/ikbrapi\/wp\/v2\/media\/272038"}],"wp:attachment":[{"href":"https:\/\/insurancekhabar.com\/ikbrapi\/wp\/v2\/media?parent=272040"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/insurancekhabar.com\/ikbrapi\/wp\/v2\/categories?post=272040"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/insurancekhabar.com\/ikbrapi\/wp\/v2\/tags?post=272040"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}